1 Bonding Technologies for 3 D I ntegration

RANSFORMATION, NTEGRATION and LOBALIZATION CONOMIC ESEARCH CENTRUM BADAWCZE TRANSFORMACJI, INTEGRACJI I GLOBALIZACJI

Hybrid characteristics of oligonucleotides consisting of isonucleoside 2',5'-anhydro-3'-deoxy-3'-(thymin-1-yl)-D-mannitol with different linkage modes.

Oligonucleotides consisting of the isonucleoside repeating unit 2',5'-anhydro-3'-deoxy-3'-(thymin-1-yl)-D-mannitol (4) were synthesized with the monomeric unit 4 incorporated into oligonucleotides as 1'-->4' linkage 4a (oligomer I) or 6'-->4' linkage 4b (oligomer II). The hybrid properties of the two oligonucleotides I and II with their complementary strands were investigated by thermal denatur...

I-38: New and Old Technologies in the Modern IVF Clinic

Background PGD has been around in various forms for over a quarter of a century now. During this time it has evolved from simple FISH and direct PCR mutation analysis to whole chromosome profiling using microarrays or next generation sequencing and improved monogene testing using STR linkage or now, recombination mapping. Modern PGD can now deliver highly accurate and reproducible results capab...

Recent Advances in High Density Area Array Interconnect Bonding for 3D Integration

The demand for more complex and multifunctional micro systems with enhanced performance characteristics for military applications is driving the electronics industry toward the use of best-of-breed materials and device technologies. Threedimensional (3-D) integration provides a way to build complex microsystems through bonding and interconnection of individually optimized device layers without ...

Observation of α-Helical Hydrogen-Bond Cooperativity in an Intact Protein.

The presence and extent of hydrogen-bonding (H-bonding) cooperativity in proteins remains a fundamental question, which in the past has been studied extensively, mostly by infrared and fluorescence measurements on model peptides. We demonstrate that such cooperativity can be studied in an intact protein by hydrogen/deuterium exchange NMR spectroscopy. The method is based on the fact that substi...